{"accession":"GO:0005667","ontology":"GO","synonyms":["cytoplasmic transcription factor complex","transcription factor complex","nuclear transcription factor complex"],"name":"transcription regulator complex","subsets":["goslim_pir"],"parents":[{"accession":"GO:0032991","ontology":"GO","synonyms":[],"definition":"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.","namespace":"cellular_component","name":"protein-containing complex","subsets":["goslim_agr","goslim_chembl","goslim_flybase_ribbon","goslim_generic","goslim_pir"]}],"namespace":"cellular_component","definition":"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.","children":[{"synonyms":[],"definition":"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.","namespace":"cellular_component","accession":"GO:0090575","ontology":"GO","subsets":[],"name":"RNA polymerase II transcription regulator complex"},{"subsets":[],"name":"RNA polymerase I transcription regulator complex","namespace":"cellular_component","synonyms":[],"definition":"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I.","ontology":"GO","accession":"GO:0000120"},{"subsets":["goslim_pir"],"name":"transcription repressor complex","ontology":"GO","accession":"GO:0017053","synonyms":["transcription factor inhibitor complex","nuclear transcriptional repressor complex","cytoplasmic transcriptional repressor complex"],"definition":"A protein complex that possesses activity that prevents or downregulates transcription.","namespace":"cellular_component"},{"namespace":"cellular_component","synonyms":[],"definition":"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase III.","accession":"GO:0090576","ontology":"GO","subsets":[],"name":"RNA polymerase III transcription regulator complex"},{"definition":"A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters.","synonyms":[],"namespace":"cellular_component","accession":"GO:0019185","ontology":"GO","subsets":[],"name":"snRNA-activating protein complex"},{"name":"ModE complex","subsets":[],"ontology":"GO","accession":"GO:1990198","namespace":"cellular_component","synonyms":["ModE dimer"],"definition":"A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism."},{"namespace":"cellular_component","synonyms":[],"definition":"A protein complex which is capable of sigma factor antagonist activity.","ontology":"GO","accession":"GO:1903865","subsets":[],"name":"sigma factor antagonist complex"},{"name":"SHREC2 complex","subsets":[],"namespace":"cellular_component","synonyms":[],"definition":"A histone deacetylase complex formed by the association of an HP1 protein with a SHREC complex. The SHREC2 complex is required for deacetylation of H3K14, and mediates transcriptional gene silencing by limiting RNA polymerase II access to heterochromatin. In fission yeast, the complex contains the SHREC subunits Clr1, Clr2, Clr3, and Mit1, and the HP1 protein Chp2.","ontology":"GO","accession":"GO:0110129"},{"subsets":[],"name":"RNA polymerase V transcription regulator complex","definition":"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase V.","synonyms":[],"namespace":"cellular_component","ontology":"GO","accession":"GO:0090578"},{"name":"RNA polymerase IV transcription regulator complex","subsets":[],"definition":"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase IV.","synonyms":[],"namespace":"cellular_component","ontology":"GO","accession":"GO:0090577"},{"name":"NuRD complex","subsets":[],"accession":"GO:0016581","ontology":"GO","synonyms":[],"definition":"An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.","namespace":"cellular_component"}]}